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xwas website  

The X chromosome plays an important role in complex human traits and diseases, especially those with sexually dimorphic characteristics. Special attention needs to be given to the analysis of X due to its unique inheritance pattern and X-inactivation. These analytical complications have resulted in exclusion or mishandling of the X chromosome in the majority of genome-wide association studies (GWAS) to date. With XWAS, we hope to provide the tools and incentive to accurately incorporate the X chromosome into GWAS, hence enabling discoveries of novel loci implicated in many diseases and in their sexual dimorphism.

Environment Modules

Run module spider xwas to find out what environment modules are available for this application.

System Variables

  • HPC_XWAS_DIR - installation directory
  • HPC_XWAS_BIN - executable directory
  • HPC_XWAS_DOC - documentation directory
  • HPC_XWAS_EXE - example directory


If you publish research that uses xwas you have to cite it as follows:

Gao F, Chang D, Biddanda A, Ma L, Guo Y, Zhou Z, Keinan A. "XWAS: a toolset for genetic data analysis and association studies of the X chromosome." Journal of Heredity. 2015;106(5):6.