Genome-wide association analysis of imputed data. ProbABEL software package is used for the analysis of genome-wide imputed SNP data and quantitative, binary, and time-till-event outcomes under linear, logistic, and Cox proportional hazards models, respectively. For quantitative traits, the package also implements a fast two-step mixed model-based score test for association in samples with differential relationships, facilitating analysis in family-based studies, studies performed in human genetically isolated populations and outbred animal populations.
module spider probabel to find out what environment modules are available for this application.
- HPC_PROBABEL_DIR - installation directory
- HPC_PROBABEL_BIN - executable directory
- HPC_PROBABEL_CONF - sample config file directory
Copy the $HPC_PROBABEL_CONF file to your working directory. Edit the resulting '
probabel_config.cfg' configuration file before trying to run the analysis.
If you publish research that uses probabel you have to cite it as follows:
Aulchenko YS, Struchalin MV, van Duijn CM. ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics. 2010 Mar 16;11:134. doi: 10.1186/1471-2105-11-134. PubMed PMID: 20233392; PubMed Central PMCID: PMC2846909.