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polyphen website  

PolyPhen-2 (Polymorphism Phenotyping v2) is a software tool which predicts possible impact of amino acid substitutions on the structure and function of human proteins using straightforward physical and evolutionary comparative considerations.

Environment Modules

Run module spider polyphen to find out what environment modules are available for this application.

System Variables

  • HPC_POLYPHEN_DIR - installation directory
  • HPC_POLYPHEN_BIN - executable directory


If you publish research that uses polyphen you have to cite it as follows:

Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. Nat Methods 7(4):248-249 (2010).