nanodisco is a toolbox for de novo discovery of all the three types (6mA, 5mC and 4mC) of DNA methylation from individual bacteria and microbiomes using nanopore sequencing. For microbiomes, nanodisco also supports the use of DNA methylation patterns as natural epigenetic barcodes to facilitate high resolution metagenomic binning. Specifically, nanodisco can be used to:
module spider nanodisco to find out what environment modules are available for this application.
- HPC_NANODISCO_DIR - installation directory
- HPC_NANODISCO_BIN - executable directory
If you publish research that uses nanodisco you have to cite it as follows:
Tourancheau, A., Mead, E.A., Zhang, XS. & Fang, G. Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing. Nat Methods (2021). doi:10.1038/s41592-021-01109-3