HMMER is used for searching sequence databases for homologs of protein sequences, and for making protein sequence alignments. It implements methods using probabilistic models called profile hidden Markov models (profile HMMs). Compared to BLAST, FASTA, and other sequence alignment and database search tools based on older scoring methodology, HMMER aims to be significantly more accurate and more able to detect remote homologs because of the strength of its underlying mathematical models. In the past, this strength came at significant computational expense, but in the new HMMER3 project, HMMER is now essentially as fast as BLAST.
module spider hmmer to find out what environment modules are available for this application.
- HPC_HMMER_DIR - installation directory
- HPC_HMMER_BIN - executable directory
phmmer and hmmsearch only work with fasta formatted target sequence databases. We provide the following fasta formatted databases either downloaded or extracted from the BLAST databases:
- UniProt - /project/bio/fasta/uniprot/uniprot_sprot.fasta
- NCBI NR - /project/bio/fasta/nr/nr.fa
- NCBI RefSeq - /project/bio/fasta/refseq/refseq_protein.fa