NONMEM

Description

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NONMEM is a nonlinear mixed effects modelling tool used in population pharmacokinetic/pharmacodynamic analysis.

• The NONMEM® program itself is a very general (non-interactive) model analysis program that can be used to fit models to many different types of data. With version 7, Monte Carlo expectation-maximization and Markov Chain Monte Carlo Bayesian methods have been added to the classical likelihood methods available in previous versions. NONMEM® can be used to simulate data as well as fit data.
• PREDPP is a powerful package of subroutines that can be used by NONMEM® to compute predictions for population pharmacokinetic and pharmacodynamic data. Use of PREDPP obviates the need for the user to code kinetic-type equations and it also allows complicated patient-type data to be easily used. However, the user can also directly and very generally code prediction-type, likelihood or -2 log-likelihood equations, and thus a great variety of different types of models can be used.
• NM-TRAN is (non-interactive) preprocessor, allowing control and other needed inputs to NONMEM/PREDPP to be specified in a user friendly manner, with quick and comprehensive detection of a variety of errors that the user may have made in so doing.

Environment Modules

Run module spider nonmem to find out what environment modules are available for this application.

System Variables

• HPC_NONMEM_DIR - installation directory
• HPC_NONMEM_BIN - executable directory
• HPC_PSN_DIR - installation directory
• HPC_PSN_BIN - executable directory