Bwa-mem2
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Description
We are happy to announce that the index size on disk is down by 8 times and in memory by 4 times due to moving to only one type of FM-index (2bit.64 instead of 2bit.64 and 8bit.32) and 8x compression of suffix array. For example, for human genome, index size on disk is down to ~10GB from ~80GB and memory footprint is down to ~10GB from ~40GB. There is a substantial reduction in index IO time due to the reduction and hardly any performance impact on read mapping. Due to this change in index structure (in commit #4b59796, 10th October 2020), you will need to rebuild the index.
Environment Modules
Run module spider Bwa-mem2 to find out what environment modules are available for this application.
System Variables
- HPC_BWA-MEM2_DIR - installation directory