SMALT aligns DNA sequencing reads with a reference genome.
Supported Sequencing Platforms
Reads from a wide range of sequencing platforms can be processed, for example Illumina, Roche-454, Ion Torrent, PacBio or ABI-Sanger. Paired reads are supported. There is no support for SOLiD reads.
The software employs a hash index of short words of up to 20 nucleotides sampled at equidistant steps along the reference genome. For each sequencing read, potentially matching segments in the reference genome are identified from seed matches in the index and subsequently aligned with the read using dynamic programming.
- Validated 4/5/2018