PolyPhen

Description

polyphen website  

PolyPhen-2 (Polymorphism Phenotyping v2) is a software tool which predicts possible impact of amino acid substitutions on the structure and function of human proteins using straightforward physical and evolutionary comparative considerations.

Required Modules

Serial

• polyphen

System Variables

• HPC_POLYPHEN_DIR - installation directory

Citation

If you publish research that uses polyphen you have to cite it as follows:

Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. Nat Methods 7(4):248-249 (2010).